http://nautil.us/issue/68/context/its-the-end-of-the-gene-as-we-know-it
We’ve all seen the stark headlines: “Being Rich and Successful Is in Your DNA” (Guardian, July 12); “A New Genetic Test Could Help Determine Children’s Success” (Newsweek, July 10); “Our Fortunetelling Genes” make us (Wall Street Journal, Nov. 16); and so on. The problem is, many of these headlines are not discussing real genes at all, but a crude statistical model of them, involving dozens of unlikely assumptions. Now, slowly but surely, that whole conceptual model of the gene is being challenged.
We have reached peak gene, and passed it.
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First, laboratory experiments have shown how living forms probably flourished as “molecular soups” long before genes existed. They self-organized, synthesized polymers (like RNA and DNA), adapted, and reproduced through interactions among hundreds of components. That means they followed “instructions” arising from relations between components, according to current conditions, with no overall controller: compositional information, as the geneticist Doron Lancet calls it.
In this perspective, the genes evolved later, as products of prior systems, not as the original designers and controllers of them. More likely as templates for components as and when needed: a kind of facility for “just in time” supply of parts needed on a recurring basis.
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Then it was slowly appreciated that we inherit just such dynamical systems from our parents, not only our genes. Eggs and sperm contain a vast variety of factors: enzymes and other proteins; amino acids; vitamins, minerals; fats; RNAs (nucleic acids other than DNA); hundreds of cell signalling factors; and other products of the parents’ genes, other than genes themselves.
Molecular biologists have been describing how those factors form networks of complex interactions. Together, they self-organize according to changing conditions around them. Being sensitive to statistical patterns in the changes, they anticipate future states, often creating novel, emergent properties to meet them.
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